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Arq. neuropsiquiatr ; 70(10): 769-773, Oct. 2012. ilus, tab
Article in English | LILACS | ID: lil-651591

ABSTRACT

OBJECTIVE: In order to compare white matter syndrome of neuropsychiatric systemic lupus erythematosus (NPSLE) and multiple sclerosis (MS), an assessment on demographic, medical history, and clinical data was proposed. METHODS: Sixty-four patients with NPSLE and 178 with MS answered a questionnaire and were evaluated regarding functional system, expanded disability status scale (EDSS), Beck depression inventory (BDI), and Beck anxiety inventory (BAI). RESULTS: The prevalence of autoimmune diseases and altered consciousness was similar in both groups, however it was higher than in the general population. Systemic signs and symptoms occurred from 2.9 to 61.9% of the MS cases, while neurological signs and symptoms occurred in 9.4 to 76.4% of the NPSLE ones. The motor, visual, and mental systems were the most affected in both diseases. The BDI in NPSLE had higher scores and the BAI in MS. CONCLUSIONS: The functional impairments in NPSLE were similar to those of MS, although greater impairment of the functional systems of cerebellar, sensitivity, and sphincters occurred in MS cases, and greater symptoms of depression, anxiety, and headache also occurred in it.


OBJETIVO: Com a finalidade de comparar a síndrome de acometimento da substância branca do lúpus neuropsiquiátrico (LESNP) e a esclerose múltipla (EM), foi proposta uma avaliação demográfica, da história médica e do exame clínico. MÉTODOS: Sessenta e quatro pacientes com LESNP e 178 com EM responderam a um questionário para avaliar o sistema funcional, a expanded disability status scale (EDSS), o Beck depression inventory (BDI) e o Beck anxiety inventory (BAI). RESULTADOS: A prevalência de doenças autoimunes e consciência alterada foi semelhante em ambos os grupos, mas foi superior comparada àquela da população geral. Sinais e sintomas sistêmicos ocorreram em 2,9 a 61,9% dos casos de EM, enquanto sinais e sintomas neurológicos foram encontrados de 9,4 a 76,4% na LESNP. Os sistemas motor, visual e mental foram os mais afetados nas duas doenças. O BDI foi superior em LESNP e o BAI na EM. CONCLUSÕES: As alterações funcionais em pacientes com LESNP foram similares às encontradas na EM, embora tenha ocorrido maior incapacidade dos sistemas funcionais cerebelar, de sensibilidade e dos esfíncteres na EM, sintomas depressivos, de ansiedade e cefaleia, também foram superiores.


Subject(s)
Humans , Disability Evaluation , Leukoencephalopathies/physiopathology , Lupus Vasculitis, Central Nervous System/physiopathology , Multiple Sclerosis/physiopathology , Nerve Fibers, Myelinated/pathology , Anxiety/etiology , Depression/etiology , Leukoencephalopathies/pathology , Lupus Vasculitis, Central Nervous System/complications , Multiple Sclerosis/complications , Psychiatric Status Rating Scales , Severity of Illness Index , Surveys and Questionnaires , Syndrome
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